Drug interactions
Memantine-donepezil + Midodrine
Severity: Minor
Memantine-donepezil and Midodrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine and midodrine's active metabolite are both eliminated partly by renal tubular secretion, so competition could slightly raise midodrine levels. The practical effect is likely small, though additive blood pressure rise or bradycardia could occur.
What this interaction means in plain words
Memantine-donepezil and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Memantine-donepezil belongs to Central Nervous System; Midodrine belongs to Miscellaneous.
Why it happens
Competition for renal tubular cationic secretion may reduce midodrine metabolite clearance.
What to do
No routine adjustment; monitor blood pressure (including supine hypertension) and heart rate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Memantine-donepezil with Midodrine?
MediHelp rates the interaction as minor. Memantine-donepezil and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine and midodrine's active metabolite are both eliminated partly by renal tubular secretion, so competition could slightly raise midodrine levels. The practical effect is likely small, though additive blood pressure rise or bradycardia could occur.
How serious is the interaction between Memantine-donepezil and Midodrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor blood pressure (including supine hypertension) and heart rate.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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