Drug interactions
Memantine-donepezil + Midostaurin
Severity: Major
Memantine-donepezil and Midostaurin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midostaurin can prolong the QT interval and donepezil has similar potential. Combined use raises the risk of torsades de pointes in patients who often have other contributing factors.
What this interaction means in plain words
Memantine-donepezil and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Memantine-donepezil belongs to Central Nervous System; Midostaurin belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Monitor ECG and electrolytes at baseline and during therapy. Consider an alternative to donepezil or hold it if QTc increases significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Midostaurin
Frequently asked questions
Can I take Memantine-donepezil with Midostaurin?
MediHelp rates the interaction as major. Memantine-donepezil and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Midostaurin can prolong the QT interval and donepezil has similar potential. Combined use raises the risk of torsades de pointes in patients who often have other contributing factors.
How serious is the interaction between Memantine-donepezil and Midostaurin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and during therapy. Consider an alternative to donepezil or hold it if QTc increases significantly.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
Full monographs, dosing and an interaction checker in the MediHelp app
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