Drug interactions
Memantine-donepezil + Mirtazapine
Severity: Minor
Memantine-donepezil and Mirtazapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine has been associated with QT prolongation, mainly in overdose or with other risk factors, and donepezil may add to this effect. The combined risk is generally small at therapeutic doses.
What this interaction means in plain words
Memantine-donepezil and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Memantine-donepezil belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation.
What to do
No dose change is usually needed; obtain an ECG if the patient has cardiac disease, electrolyte abnormalities or takes other QT-prolonging drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Memantine-donepezil with Mirtazapine?
MediHelp rates the interaction as minor. Memantine-donepezil and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mirtazapine has been associated with QT prolongation, mainly in overdose or with other risk factors, and donepezil may add to this effect. The combined risk is generally small at therapeutic doses.
How serious is the interaction between Memantine-donepezil and Mirtazapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; obtain an ECG if the patient has cardiac disease, electrolyte abnormalities or takes other QT-prolonging drugs.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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