Drug interactions
Memantine-donepezil + Ozanimod
Severity: Moderate
Memantine-donepezil and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and conduction at initiation, and donepezil also causes bradycardia and can prolong QT. The combination may add to the risk of bradyarrhythmia and torsades de pointes.
What this interaction means in plain words
Memantine-donepezil and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine-donepezil belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Additive bradycardic and QT-prolonging effects, from S1P receptor modulation and cholinesterase inhibition.
What to do
Review baseline ECG and heart rate before starting ozanimod and use dose titration. Monitor for bradycardia, dizziness and syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Memantine-donepezil with Ozanimod?
MediHelp rates the interaction as moderate. Memantine-donepezil and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and conduction at initiation, and donepezil also causes bradycardia and can prolong QT. The combination may add to the risk of bradyarrhythmia and torsades de pointes.
How serious is the interaction between Memantine-donepezil and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review baseline ECG and heart rate before starting ozanimod and use dose titration. Monitor for bradycardia, dizziness and syncope.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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