Drug interactions
Memantine-donepezil + Risperidone
Severity: Moderate
Memantine-donepezil and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both donepezil and risperidone may prolong the QT interval, and donepezil can cause bradycardia. Combined use may increase arrhythmia risk in older patients, who often take both drugs for dementia-related symptoms.
What this interaction means in plain words
Memantine-donepezil and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine-donepezil belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Use the lowest effective risperidone dose and review the need regularly. Obtain an ECG if there are cardiac risk factors and correct electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Memantine-donepezil with Risperidone?
MediHelp rates the interaction as moderate. Memantine-donepezil and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both donepezil and risperidone may prolong the QT interval, and donepezil can cause bradycardia. Combined use may increase arrhythmia risk in older patients, who often take both drugs for dementia-related symptoms.
How serious is the interaction between Memantine-donepezil and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective risperidone dose and review the need regularly. Obtain an ECG if there are cardiac risk factors and correct electrolytes.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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