Drug interactions
Memantine-donepezil + Trazodone
Severity: Moderate
Memantine-donepezil and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone can prolong the QT interval and has been associated with arrhythmias, and donepezil may add to this risk. The risk is greater in older patients, those with heart disease or those with electrolyte abnormalities, who are the same patients commonly treated with donepezil.
What this interaction means in plain words
Memantine-donepezil and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine-donepezil belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Use the lowest effective trazodone dose and consider a baseline ECG in patients with cardiac risk factors. Correct electrolyte disturbances and avoid adding further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Memantine-donepezil with Trazodone?
MediHelp rates the interaction as moderate. Memantine-donepezil and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone can prolong the QT interval and has been associated with arrhythmias, and donepezil may add to this risk. The risk is greater in older patients, those with heart disease or those with electrolyte abnormalities, who are the same patients commonly treated with donepezil.
How serious is the interaction between Memantine-donepezil and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective trazodone dose and consider a baseline ECG in patients with cardiac risk factors. Correct electrolyte disturbances and avoid adding further QT-prolonging drugs.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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