Drug interactions
Meperidine + Paliperidone
Severity: Moderate
Meperidine and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can depress the central nervous system, so drowsiness and impaired alertness may be increased. Meperidine is also serotonergic and paliperidone blocks 5-HT2A and dopamine receptors, so rare serotonin toxicity or neuroleptic malignant syndrome has been described with such combinations. Orthostatic hypotension may also be additive.
What this interaction means in plain words
Meperidine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meperidine belongs to Musculoskeletal; Paliperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression plus possible serotonergic and dopamine-blocking pharmacodynamic effects.
What to do
Start at low doses and monitor for sedation, orthostatic hypotension, and signs of serotonin toxicity (agitation, clonus, hyperthermia) or rigidity. Reduce doses if excess sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Meperidine with Paliperidone?
MediHelp rates the interaction as moderate. Meperidine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can depress the central nervous system, so drowsiness and impaired alertness may be increased. Meperidine is also serotonergic and paliperidone blocks 5-HT2A and dopamine receptors, so rare serotonin toxicity or neuroleptic malignant syndrome has been described with such combinations. Orthostatic hypotension may also be additive.
How serious is the interaction between Meperidine and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start at low doses and monitor for sedation, orthostatic hypotension, and signs of serotonin toxicity (agitation, clonus, hyperthermia) or rigidity. Reduce doses if excess sedation occurs.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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