Drug interactions
Mesalamine + Metolazone
Severity: Minor
Mesalamine and Metolazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone and the acetylated mesalamine metabolite are both secreted by renal tubular transporters, so competition might slightly raise mesalamine exposure. Diuretic-related volume depletion could add to renal stress in susceptible patients.
What this interaction means in plain words
Mesalamine and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mesalamine belongs to Gastrointestinal Tract; Metolazone belongs to Cardiovascular.
Why it happens
Possible competition for renal tubular anion secretion.
What to do
No dose adjustment is generally needed; monitor renal function periodically during long-term combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mesalamine
Other interactions of Metolazone
Frequently asked questions
Can I take Mesalamine with Metolazone?
MediHelp rates the interaction as minor. Mesalamine and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metolazone and the acetylated mesalamine metabolite are both secreted by renal tubular transporters, so competition might slightly raise mesalamine exposure. Diuretic-related volume depletion could add to renal stress in susceptible patients.
How serious is the interaction between Mesalamine and Metolazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor renal function periodically during long-term combined use.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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