Drug interactions
Mesterolone + Rosuvastatin
Severity: Minor
Mesterolone and Rosuvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The concern is extrapolated from danazol with other statins, where myopathy and rhabdomyolysis were reported. Rosuvastatin undergoes little CYP metabolism, and mesterolone has no established effect on its exposure.
What this interaction means in plain words
Mesterolone and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mesterolone belongs to Endocrine; Rosuvastatin belongs to Cardiovascular.
Why it happens
No established mechanism; a possible additive myotoxic or metabolic effect is only theoretical.
What to do
No dose change is needed. Monitor for muscle pain or weakness and check creatine kinase if symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rosuvastatin
Other interactions of Mesterolone
Frequently asked questions
Can I take Mesterolone with Rosuvastatin?
MediHelp rates the interaction as minor. Mesterolone and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The concern is extrapolated from danazol with other statins, where myopathy and rhabdomyolysis were reported. Rosuvastatin undergoes little CYP metabolism, and mesterolone has no established effect on its exposure.
How serious is the interaction between Mesterolone and Rosuvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for muscle pain or weakness and check creatine kinase if symptoms appear.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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