Drug interactions
Metaxalone + Oxycodone
Severity: Moderate
Metaxalone and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaxalone is a sedating muscle relaxant and can increase the drowsiness, dizziness and respiratory depression caused by oxycodone. The risk rises with higher doses, older age and other sedatives.
What this interaction means in plain words
Metaxalone and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive CNS depression.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression. Advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Oxycodone?
MediHelp rates the interaction as moderate. Metaxalone and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaxalone is a sedating muscle relaxant and can increase the drowsiness, dizziness and respiratory depression caused by oxycodone. The risk rises with higher doses, older age and other sedatives.
How serious is the interaction between Metaxalone and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression. Advise against driving until the response is known.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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