Drug interactions
Metaxalone + Risperidone
Severity: Moderate
Metaxalone and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause somnolence and dizziness, and metaxalone may add to these effects. This increases the risk of impaired alertness and falls, especially in older patients.
What this interaction means in plain words
Metaxalone and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for sedation and orthostatic dizziness and counsel on avoiding driving until tolerance is established. Reduce the dose of one drug if symptoms are bothersome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Metaxalone with Risperidone?
MediHelp rates the interaction as moderate. Metaxalone and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can cause somnolence and dizziness, and metaxalone may add to these effects. This increases the risk of impaired alertness and falls, especially in older patients.
How serious is the interaction between Metaxalone and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic dizziness and counsel on avoiding driving until tolerance is established. Reduce the dose of one drug if symptoms are bothersome.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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