Drug interactions
Metaxalone + Rucaparib
Severity: Minor
Metaxalone and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and other enzymes and may modestly raise concentrations of metaxalone. This could increase drowsiness or other adverse effects.
What this interaction means in plain words
Metaxalone and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metaxalone belongs to Musculoskeletal; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4, reducing metaxalone metabolism.
What to do
Monitor for increased sedation or dizziness. Lower the metaxalone dose if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metaxalone
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Metaxalone with Rucaparib?
MediHelp rates the interaction as minor. Metaxalone and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and other enzymes and may modestly raise concentrations of metaxalone. This could increase drowsiness or other adverse effects.
How serious is the interaction between Metaxalone and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation or dizziness. Lower the metaxalone dose if adverse effects appear.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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