Drug interactions
Metaxalone + Stiripentol
Severity: Moderate
Metaxalone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol is a sedating antiepileptic that also alters CYP3A4 activity, and metaxalone is a skeletal muscle relaxant with CNS depressant effects. Together they may increase drowsiness and somnolence, and metaxalone exposure may change unpredictably.
What this interaction means in plain words
Metaxalone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression plus stiripentol's mixed CYP3A4 inhibition and induction, which may alter metaxalone metabolism.
What to do
Monitor for excessive sedation and for changes in muscle relaxant effect when starting or stopping stiripentol. Reduce the metaxalone dose if sedation occurs and advise against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Stiripentol
Frequently asked questions
Can I take Metaxalone with Stiripentol?
MediHelp rates the interaction as moderate. Metaxalone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol is a sedating antiepileptic that also alters CYP3A4 activity, and metaxalone is a skeletal muscle relaxant with CNS depressant effects. Together they may increase drowsiness and somnolence, and metaxalone exposure may change unpredictably.
How serious is the interaction between Metaxalone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and for changes in muscle relaxant effect when starting or stopping stiripentol. Reduce the metaxalone dose if sedation occurs and advise against driving.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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