Drug interactions
Metaxalone + Tramadol
Severity: Moderate
Metaxalone and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaxalone is a sedating muscle relaxant, and with tramadol it can increase drowsiness, dizziness and impaired psychomotor performance. Metaxalone has also been linked to serotonin syndrome in rare cases when combined with serotonergic drugs.
What this interaction means in plain words
Metaxalone and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Tramadol belongs to Musculoskeletal.
Why it happens
Additive CNS depression, with possible weak serotonergic contribution.
What to do
Use the lowest effective doses and monitor for sedation and signs of serotonin toxicity. Advise against alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Tramadol?
MediHelp rates the interaction as moderate. Metaxalone and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaxalone is a sedating muscle relaxant, and with tramadol it can increase drowsiness, dizziness and impaired psychomotor performance. Metaxalone has also been linked to serotonin syndrome in rare cases when combined with serotonergic drugs.
How serious is the interaction between Metaxalone and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and signs of serotonin toxicity. Advise against alcohol and driving.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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