Drug interactions
Metaxalone + Trazodone
Severity: Moderate
Metaxalone and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone is sedating, and metaxalone may add to drowsiness and dizziness. Metaxalone has also been associated with serotonin syndrome in labeling, so the combination of two agents with serotonergic potential deserves attention.
What this interaction means in plain words
Metaxalone and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression, with a possible additive serotonergic effect.
What to do
Monitor for oversedation and for signs of serotonin toxicity such as agitation, tremor, sweating or hyperreflexia. Use the lowest effective doses and counsel on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Metaxalone with Trazodone?
MediHelp rates the interaction as moderate. Metaxalone and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone is sedating, and metaxalone may add to drowsiness and dizziness. Metaxalone has also been associated with serotonin syndrome in labeling, so the combination of two agents with serotonergic potential deserves attention.
How serious is the interaction between Metaxalone and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and for signs of serotonin toxicity such as agitation, tremor, sweating or hyperreflexia. Use the lowest effective doses and counsel on driving.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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