Drug interactions
Metformin-pioglitazone + Vilazodone
Severity: Minor
Metformin-pioglitazone and Vilazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonergic antidepressants may rarely alter glucose levels, including hypoglycemia, in patients taking antidiabetic drugs. The effect with metformin and pioglitazone is small.
What this interaction means in plain words
Metformin-pioglitazone and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-pioglitazone belongs to Endocrine; Vilazodone belongs to Central Nervous System.
Why it happens
Possible pharmacodynamic effect on glucose homeostasis; not well established.
What to do
Monitor blood glucose after starting or changing vilazodone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Metformin-pioglitazone with Vilazodone?
MediHelp rates the interaction as minor. Metformin-pioglitazone and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Serotonergic antidepressants may rarely alter glucose levels, including hypoglycemia, in patients taking antidiabetic drugs. The effect with metformin and pioglitazone is small.
How serious is the interaction between Metformin-pioglitazone and Vilazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing vilazodone.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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