Drug interactions
Metformin-repaglinide + Pacritinib
Severity: Moderate
Metformin-repaglinide and Pacritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib inhibits OCT1, which mediates hepatic uptake of metformin. Altered metformin exposure may change glucose-lowering effect and tolerability.
What this interaction means in plain words
Metformin-repaglinide and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Pacritinib belongs to Oncology.
Why it happens
OCT1 inhibition alters hepatic uptake of metformin.
What to do
Monitor blood glucose and metformin tolerability, adjusting the dose when needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Metformin-repaglinide with Pacritinib?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pacritinib inhibits OCT1, which mediates hepatic uptake of metformin. Altered metformin exposure may change glucose-lowering effect and tolerability.
How serious is the interaction between Metformin-repaglinide and Pacritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and metformin tolerability, adjusting the dose when needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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