Drug interactions
Metformin-repaglinide + Pentamidine
Severity: Moderate
Metformin-repaglinide and Pentamidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine can damage pancreatic beta cells, causing initial hypoglycemia followed by hyperglycemia or diabetes. This can unpredictably alter the response to metformin and repaglinide, and hypoglycemia may be enhanced with repaglinide.
What this interaction means in plain words
Metformin-repaglinide and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Pentamidine belongs to Anti Parasitic.
Why it happens
Pentamidine is toxic to pancreatic beta cells, producing dysglycemia that alters antidiabetic requirements.
What to do
Monitor blood glucose frequently during and after pentamidine therapy and adjust antidiabetic doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Pentamidine?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentamidine can damage pancreatic beta cells, causing initial hypoglycemia followed by hyperglycemia or diabetes. This can unpredictably alter the response to metformin and repaglinide, and hypoglycemia may be enhanced with repaglinide.
How serious is the interaction between Metformin-repaglinide and Pentamidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during and after pentamidine therapy and adjust antidiabetic doses accordingly.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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