Drug interactions
Metformin-repaglinide + Posaconazole
Severity: Moderate
Metformin-repaglinide and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor and may raise repaglinide concentrations, increasing the risk of hypoglycemia. Repaglinide is also cleared by CYP2C8, so the effect is likely smaller than with combined inhibitors.
What this interaction means in plain words
Metformin-repaglinide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4-mediated repaglinide metabolism.
What to do
Monitor blood glucose closely and consider reducing the repaglinide dose during posaconazole therapy. Counsel on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Posaconazole?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole is a strong CYP3A4 inhibitor and may raise repaglinide concentrations, increasing the risk of hypoglycemia. Repaglinide is also cleared by CYP2C8, so the effect is likely smaller than with combined inhibitors.
How serious is the interaction between Metformin-repaglinide and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and consider reducing the repaglinide dose during posaconazole therapy. Counsel on hypoglycemia symptoms.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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