Drug interactions
Metformin-repaglinide + Teclistamab
Severity: Moderate
Metformin-repaglinide and Teclistamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teclistamab triggers cytokine release that may transiently suppress CYP enzymes and increase exposure to repaglinide. The effect is mainly expected around step-up doses and cytokine release syndrome, with hypoglycemia as the risk.
What this interaction means in plain words
Metformin-repaglinide and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Teclistamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP450 enzymes reduces repaglinide metabolism.
What to do
Monitor blood glucose during step-up dosing and cytokine release syndrome, and reduce repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Teclistamab
- Pimozide + Teclistamab Major
- Carbamazepine + Teclistamab Moderate
- Colchicine + Teclistamab Moderate
- Cyclosporin + Teclistamab Moderate
- Divalproex + Teclistamab Moderate
- Ergotamine + Teclistamab Moderate
Frequently asked questions
Can I take Metformin-repaglinide with Teclistamab?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teclistamab triggers cytokine release that may transiently suppress CYP enzymes and increase exposure to repaglinide. The effect is mainly expected around step-up doses and cytokine release syndrome, with hypoglycemia as the risk.
How serious is the interaction between Metformin-repaglinide and Teclistamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during step-up dosing and cytokine release syndrome, and reduce repaglinide dose if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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