Drug interactions
Metformin-repaglinide + Teriflunomide
Severity: Moderate
Metformin-repaglinide and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide weakly inhibits CYP2C8 and increases exposure to CYP2C8 substrates such as repaglinide, which may lead to hypoglycemia.
What this interaction means in plain words
Metformin-repaglinide and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Teriflunomide belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C8-mediated repaglinide metabolism.
What to do
Monitor blood glucose and consider lowering repaglinide dose when teriflunomide is started.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Teriflunomide
Frequently asked questions
Can I take Metformin-repaglinide with Teriflunomide?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teriflunomide weakly inhibits CYP2C8 and increases exposure to CYP2C8 substrates such as repaglinide, which may lead to hypoglycemia.
How serious is the interaction between Metformin-repaglinide and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and consider lowering repaglinide dose when teriflunomide is started.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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