Drug interactions
Methadone + Perampanel
Severity: Moderate
Methadone and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel can cause somnolence, dizziness and CNS depression, which may add to the effects of methadone. Perampanel also has a weak enzyme-inducing effect that is of uncertain relevance to methadone.
What this interaction means in plain words
Methadone and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methadone belongs to Musculoskeletal; Perampanel belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible weak CYP3A4 induction by perampanel.
What to do
Monitor for excessive sedation, dizziness and psychomotor impairment, and advise caution when driving. Adjust doses if CNS depression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Methadone with Perampanel?
MediHelp rates the interaction as moderate. Methadone and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel can cause somnolence, dizziness and CNS depression, which may add to the effects of methadone. Perampanel also has a weak enzyme-inducing effect that is of uncertain relevance to methadone.
How serious is the interaction between Methadone and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, dizziness and psychomotor impairment, and advise caution when driving. Adjust doses if CNS depression occurs.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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