Drug interactions
Methamphetamine + Propafenone
Severity: Moderate
Methamphetamine and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine is partly metabolized by CYP2D6, which propafenone inhibits, so methamphetamine exposure may increase. Greater sympathomimetic effects can provoke tachycardia, hypertension and arrhythmias, which may counteract or complicate antiarrhythmic therapy.
What this interaction means in plain words
Methamphetamine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Propafenone belongs to Cardiovascular.
Why it happens
Propafenone inhibits CYP2D6 metabolism of methamphetamine, with opposing pharmacodynamic cardiac effects.
What to do
Monitor heart rate, blood pressure and rhythm, and lower the methamphetamine dose if sympathomimetic effects increase. Consider an alternative if arrhythmia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Propafenone?
MediHelp rates the interaction as moderate. Methamphetamine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methamphetamine is partly metabolized by CYP2D6, which propafenone inhibits, so methamphetamine exposure may increase. Greater sympathomimetic effects can provoke tachycardia, hypertension and arrhythmias, which may counteract or complicate antiarrhythmic therapy.
How serious is the interaction between Methamphetamine and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and rhythm, and lower the methamphetamine dose if sympathomimetic effects increase. Consider an alternative if arrhythmia occurs.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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