Drug interactions
Methamphetamine + Sertraline
Severity: Major
Methamphetamine and Sertraline: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline may modestly raise methamphetamine exposure by inhibiting CYP2D6, and both drugs affect serotonergic and sympathomimetic activity. This raises the risk of agitation, hypertension, tachycardia and serotonin toxicity.
What this interaction means in plain words
Methamphetamine and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methamphetamine belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by sertraline combined with additive serotonergic and sympathomimetic effects.
What to do
Avoid concurrent use where possible. If it cannot be avoided, monitor blood pressure, heart rate and signs of serotonin syndrome.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Sertraline?
MediHelp rates the interaction as major. Methamphetamine and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sertraline may modestly raise methamphetamine exposure by inhibiting CYP2D6, and both drugs affect serotonergic and sympathomimetic activity. This raises the risk of agitation, hypertension, tachycardia and serotonin toxicity.
How serious is the interaction between Methamphetamine and Sertraline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If it cannot be avoided, monitor blood pressure, heart rate and signs of serotonin syndrome.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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