Drug interactions
Methamphetamine + Sufentanil
Severity: Moderate
Methamphetamine and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a potent opioid that causes sedation and respiratory depression, while methamphetamine is a stimulant. Stimulation may mask opioid-induced sedation, but it does not reliably prevent respiratory depression.
What this interaction means in plain words
Methamphetamine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Opposing pharmacodynamic effects on arousal; stimulant effects do not reverse opioid-mediated respiratory depression.
What to do
Monitor respiratory rate and oxygen saturation in addition to alertness. Do not use methamphetamine to counter opioid effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Methamphetamine with Sufentanil?
MediHelp rates the interaction as moderate. Methamphetamine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is a potent opioid that causes sedation and respiratory depression, while methamphetamine is a stimulant. Stimulation may mask opioid-induced sedation, but it does not reliably prevent respiratory depression.
How serious is the interaction between Methamphetamine and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate and oxygen saturation in addition to alertness. Do not use methamphetamine to counter opioid effects.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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