Drug interactions
Methamphetamine + Tranylcypromine
Severity: Contraindicated
Methamphetamine and Tranylcypromine: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine with an MAO inhibitor can trigger a hypertensive crisis with severe headache, arrhythmias, intracranial hemorrhage and hyperpyrexia. Serotonergic toxicity is also possible.
What this interaction means in plain words
Methamphetamine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Methamphetamine belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAO inhibition blocks degradation of catecholamines released by methamphetamine, producing exaggerated sympathomimetic effects.
What to do
Avoid during MAO inhibitor therapy and for 14 days after stopping it. Use non-sympathomimetic alternatives.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Methamphetamine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methamphetamine with an MAO inhibitor can trigger a hypertensive crisis with severe headache, arrhythmias, intracranial hemorrhage and hyperpyrexia. Serotonergic toxicity is also possible.
How serious is the interaction between Methamphetamine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during MAO inhibitor therapy and for 14 days after stopping it. Use non-sympathomimetic alternatives.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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