Drug interactions
Methocarbamol + Mirtazapine
Severity: Moderate
Methocarbamol and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine is strongly sedating through histamine H1 blockade, and methocarbamol adds further central depression. Patients may experience excessive drowsiness, dizziness and impaired psychomotor function.
What this interaction means in plain words
Methocarbamol and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methocarbamol belongs to Musculoskeletal; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through pharmacodynamic synergism.
What to do
Advise patients to avoid driving until the combined effect is known. Reduce the dose of one agent if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Methocarbamol with Mirtazapine?
MediHelp rates the interaction as moderate. Methocarbamol and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirtazapine is strongly sedating through histamine H1 blockade, and methocarbamol adds further central depression. Patients may experience excessive drowsiness, dizziness and impaired psychomotor function.
How serious is the interaction between Methocarbamol and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving until the combined effect is known. Reduce the dose of one agent if sedation is excessive.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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