Drug interactions
Methohexital + Mirtazapine
Severity: Moderate
Methohexital and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can deepen sedation and prolong recovery after methohexital anesthesia. Hypotension and respiratory depression may be enhanced.
What this interaction means in plain words
Methohexital and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methohexital belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and H1 antagonism.
What to do
Titrate methohexital to effect with a reduced dose and monitor airway, ventilation and blood pressure through recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Mirtazapine?
MediHelp rates the interaction as moderate. Methohexital and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can deepen sedation and prolong recovery after methohexital anesthesia. Hypotension and respiratory depression may be enhanced.
How serious is the interaction between Methohexital and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital to effect with a reduced dose and monitor airway, ventilation and blood pressure through recovery.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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