Drug interactions
Methohexital + Pregabalin
Severity: Moderate
Methohexital and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin and methohexital, a short-acting barbiturate anesthetic, both depress the central nervous system, so combined use may deepen sedation and increase respiratory depression. The effect is mainly relevant in procedural sedation or anesthesia.
What this interaction means in plain words
Methohexital and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methohexital belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive central nervous system depression; methohexital enhances GABA-A receptor activity while pregabalin reduces excitatory neurotransmitter release.
What to do
Titrate methohexital carefully and expect a lower dose requirement in patients taking pregabalin. Monitor respiratory function and oxygenation throughout and during recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Pregabalin?
MediHelp rates the interaction as moderate. Methohexital and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pregabalin and methohexital, a short-acting barbiturate anesthetic, both depress the central nervous system, so combined use may deepen sedation and increase respiratory depression. The effect is mainly relevant in procedural sedation or anesthesia.
How serious is the interaction between Methohexital and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital carefully and expect a lower dose requirement in patients taking pregabalin. Monitor respiratory function and oxygenation throughout and during recovery.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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