Drug interactions
Methohexital + Sevoflurane
Severity: Moderate
Methohexital and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital, a barbiturate, and sevoflurane both depress the central nervous system. Combined, they cause deeper sedation, greater hypotension and respiratory depression than either alone. This pairing is routine in anesthesia, so the effect is expected and manageable by dose titration.
What this interaction means in plain words
Methohexital and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methohexital belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression through enhanced GABA-A receptor activity.
What to do
Titrate each agent to effect with continuous monitoring of ventilation, oxygenation and blood pressure. Expect to use a lower sevoflurane concentration after a methohexital induction dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Sevoflurane?
MediHelp rates the interaction as moderate. Methohexital and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital, a barbiturate, and sevoflurane both depress the central nervous system. Combined, they cause deeper sedation, greater hypotension and respiratory depression than either alone. This pairing is routine in anesthesia, so the effect is expected and manageable by dose titration.
How serious is the interaction between Methohexital and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate each agent to effect with continuous monitoring of ventilation, oxygenation and blood pressure. Expect to use a lower sevoflurane concentration after a methohexital induction dose.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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