Drug interactions
Methohexital + Tramadol
Severity: Moderate
Methohexital and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a barbiturate anesthetic, and with tramadol it adds CNS and respiratory depression and hypotension. Tramadol also lowers the seizure threshold, and methohexital can itself provoke seizure activity.
What this interaction means in plain words
Methohexital and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methohexital belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid and barbiturate GABA-A effects.
What to do
Reduce methohexital dose as needed and monitor airway, respiration and blood pressure with continuous monitoring during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Tramadol?
MediHelp rates the interaction as moderate. Methohexital and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a barbiturate anesthetic, and with tramadol it adds CNS and respiratory depression and hypotension. Tramadol also lowers the seizure threshold, and methohexital can itself provoke seizure activity.
How serious is the interaction between Methohexital and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce methohexital dose as needed and monitor airway, respiration and blood pressure with continuous monitoring during anesthesia.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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