Drug interactions
Methohexital + Trazodone
Severity: Moderate
Methohexital and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anesthetic, and trazodone adds sedation and hypotension. Together they may deepen sedation and cause greater cardiovascular and respiratory depression.
What this interaction means in plain words
Methohexital and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methohexital belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotensive effects.
What to do
Titrate methohexital carefully and monitor blood pressure, oxygenation and respiration. Inform the anesthesia team that the patient takes trazodone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Trazodone?
MediHelp rates the interaction as moderate. Methohexital and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a short-acting barbiturate anesthetic, and trazodone adds sedation and hypotension. Together they may deepen sedation and cause greater cardiovascular and respiratory depression.
How serious is the interaction between Methohexital and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital carefully and monitor blood pressure, oxygenation and respiration. Inform the anesthesia team that the patient takes trazodone.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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