Drug interactions
Methohexital + Vigabatrin
Severity: Moderate
Methohexital and Vigabatrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anesthetic that causes profound CNS and respiratory depression. Vigabatrin's sedative effects may add to this, though the interaction is mainly relevant in the procedural setting.
What this interaction means in plain words
Methohexital and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methohexital belongs to Central Nervous System; Vigabatrin belongs to Central Nervous System.
Why it happens
Additive CNS depression through pharmacodynamic effects.
What to do
Inform the anesthesia team of vigabatrin use and titrate methohexital to effect with continuous monitoring of respiration and oxygenation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vigabatrin
- Amisulpride + Vigabatrin Moderate
- Asenapine transdermal + Vigabatrin Moderate
- Asenapine + Vigabatrin Moderate
- Avapritinib + Vigabatrin Moderate
- Benzhydrocodone / acetaminophen + Vigabatrin Moderate
- Brexanolone + Vigabatrin Moderate
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Vigabatrin?
MediHelp rates the interaction as moderate. Methohexital and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a short-acting barbiturate anesthetic that causes profound CNS and respiratory depression. Vigabatrin's sedative effects may add to this, though the interaction is mainly relevant in the procedural setting.
How serious is the interaction between Methohexital and Vigabatrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of vigabatrin use and titrate methohexital to effect with continuous monitoring of respiration and oxygenation.
What other medicines interact with Vigabatrin?
MediHelp also lists interactions of Vigabatrin with, for example, Amisulpride, Asenapine transdermal, Asenapine. The full list is on the Vigabatrin page.
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