Drug interactions
Methoxsalen + Metolazone
Severity: Moderate
Methoxsalen and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone, like other thiazide-related drugs, can cause photosensitivity. Combined with methoxsalen, which is used with UVA for photochemotherapy, the risk of exaggerated phototoxic skin reactions may increase.
What this interaction means in plain words
Methoxsalen and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methoxsalen belongs to Anti Fungals; Metolazone belongs to Cardiovascular.
Why it happens
Additive photosensitizing effects of two agents that increase skin sensitivity to ultraviolet light.
What to do
Counsel the patient on strict sun protection and adjust the UVA dose conservatively during treatment. Monitor the skin for erythema or burns after sessions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Methoxsalen with Metolazone?
MediHelp rates the interaction as moderate. Methoxsalen and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone, like other thiazide-related drugs, can cause photosensitivity. Combined with methoxsalen, which is used with UVA for photochemotherapy, the risk of exaggerated phototoxic skin reactions may increase.
How serious is the interaction between Methoxsalen and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on strict sun protection and adjust the UVA dose conservatively during treatment. Monitor the skin for erythema or burns after sessions.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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