Drug interactions
Methsuximide + Midazolam
Severity: Moderate
Methsuximide and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methsuximide is a sedating anticonvulsant, and with midazolam it can increase drowsiness and respiratory depression. Its active metabolite may also influence CYP enzymes and alter midazolam levels.
What this interaction means in plain words
Methsuximide and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methsuximide belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible enzyme induction by methsuximide.
What to do
Titrate midazolam to effect and monitor sedation and respiratory status. Adjust doses if the response differs from expected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Methsuximide
- Amisulpride + Methsuximide Moderate
- Amobarbital + Methsuximide Moderate
- Apalutamide + Methsuximide Moderate
- Asenapine + Methsuximide Moderate
- Brexpiprazole + Methsuximide Moderate
- Brivaracetam + Methsuximide Moderate
Frequently asked questions
Can I take Methsuximide with Midazolam?
MediHelp rates the interaction as moderate. Methsuximide and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methsuximide is a sedating anticonvulsant, and with midazolam it can increase drowsiness and respiratory depression. Its active metabolite may also influence CYP enzymes and alter midazolam levels.
How serious is the interaction between Methsuximide and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate midazolam to effect and monitor sedation and respiratory status. Adjust doses if the response differs from expected.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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