Drug interactions
Methyldopa + Metoclopramide
Severity: Moderate
Methyldopa and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide may alter methyldopa exposure, and the two have opposing effects on dopamine pathways. Methyldopa can also worsen extrapyramidal effects of metoclopramide, and blood pressure control may change.
What this interaction means in plain words
Methyldopa and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methyldopa belongs to Cardiovascular; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Pharmacodynamic interaction via dopamine antagonism and altered gastrointestinal absorption of methyldopa; the mechanism is not well established.
What to do
Monitor blood pressure and extrapyramidal symptoms when combined, and adjust the methyldopa dose as needed. Consider another antiemetic if movement symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Methyldopa
- Methyldopa + Tranylcypromine Contraindicated
- Iobenguane i + Methyldopa Major
- Lofexidine + Methyldopa Major
- Methyldopa + Pexidartinib Major
- Methyldopa + Pretomanid Major
- Methyldopa + Thioridazine Major
Frequently asked questions
Can I take Methyldopa with Metoclopramide?
MediHelp rates the interaction as moderate. Methyldopa and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide may alter methyldopa exposure, and the two have opposing effects on dopamine pathways. Methyldopa can also worsen extrapyramidal effects of metoclopramide, and blood pressure control may change.
How serious is the interaction between Methyldopa and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and extrapyramidal symptoms when combined, and adjust the methyldopa dose as needed. Consider another antiemetic if movement symptoms appear.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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