Drug interactions
Methylprednisolone + Nimodipine
Severity: Minor
Methylprednisolone and Nimodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylprednisolone is a weak CYP3A4 inducer at most, and any reduction in nimodipine exposure is likely small and not well documented. The clinical relevance is uncertain.
What this interaction means in plain words
Methylprednisolone and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methylprednisolone belongs to Endocrine; Nimodipine belongs to Cardiovascular.
Why it happens
Possible weak induction of CYP3A4 by glucocorticoids, which could modestly increase nimodipine metabolism; not firmly established.
What to do
No routine adjustment is needed; watch blood pressure and clinical response to nimodipine if a high-dose steroid course is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Methylprednisolone with Nimodipine?
MediHelp rates the interaction as minor. Methylprednisolone and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methylprednisolone is a weak CYP3A4 inducer at most, and any reduction in nimodipine exposure is likely small and not well documented. The clinical relevance is uncertain.
How serious is the interaction between Methylprednisolone and Nimodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch blood pressure and clinical response to nimodipine if a high-dose steroid course is prolonged.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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