Drug interactions
Methylprednisolone + Pneumococcal vaccine 13-valent
Severity: Minor
Methylprednisolone and Pneumococcal vaccine 13-valent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppressive doses of corticosteroids can reduce the antibody response to inactivated vaccines. The 13-valent conjugate vaccine is non-live and is not contraindicated, though protection may be weaker.
What this interaction means in plain words
Methylprednisolone and Pneumococcal vaccine 13-valent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methylprednisolone belongs to Endocrine; Pneumococcal vaccine 13-valent belongs to Miscellaneous.
Why it happens
Corticosteroid-induced immunosuppression blunts the vaccine immune response.
What to do
Vaccinate as indicated, ideally before starting prolonged high-dose steroids if feasible. Do not delay vaccination because of steroid use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Frequently asked questions
Can I take Methylprednisolone with Pneumococcal vaccine 13-valent?
MediHelp rates the interaction as minor. Methylprednisolone and Pneumococcal vaccine 13-valent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Immunosuppressive doses of corticosteroids can reduce the antibody response to inactivated vaccines. The 13-valent conjugate vaccine is non-live and is not contraindicated, though protection may be weaker.
How serious is the interaction between Methylprednisolone and Pneumococcal vaccine 13-valent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as indicated, ideally before starting prolonged high-dose steroids if feasible. Do not delay vaccination because of steroid use.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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