Drug interactions
Methylprednisolone + Tolfenamic acid
Severity: Moderate
Methylprednisolone and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking a corticosteroid with an NSAID raises the risk of gastrointestinal ulceration and bleeding. The risk is greater in older patients and with prolonged use.
What this interaction means in plain words
Methylprednisolone and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methylprednisolone belongs to Endocrine; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal injury from prostaglandin inhibition and impaired mucosal healing.
What to do
Use the shortest possible duration and consider a proton pump inhibitor for gastroprotection. Counsel patients to report black stools or abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Methylprednisolone with Tolfenamic acid?
MediHelp rates the interaction as moderate. Methylprednisolone and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking a corticosteroid with an NSAID raises the risk of gastrointestinal ulceration and bleeding. The risk is greater in older patients and with prolonged use.
How serious is the interaction between Methylprednisolone and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest possible duration and consider a proton pump inhibitor for gastroprotection. Counsel patients to report black stools or abdominal pain.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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