Drug interactions
Methylprednisolone + Zafirlukast
Severity: Minor
Methylprednisolone and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast is a CYP3A4 inhibitor in vitro and could raise methylprednisolone levels. The clinical significance is likely modest and the evidence is limited.
What this interaction means in plain words
Methylprednisolone and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methylprednisolone belongs to Endocrine; Zafirlukast belongs to Respiratory.
Why it happens
Zafirlukast may weakly inhibit CYP3A4, slowing methylprednisolone metabolism.
What to do
No routine dose change is needed; monitor for increased corticosteroid effects if high doses or prolonged courses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Frequently asked questions
Can I take Methylprednisolone with Zafirlukast?
MediHelp rates the interaction as minor. Methylprednisolone and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast is a CYP3A4 inhibitor in vitro and could raise methylprednisolone levels. The clinical significance is likely modest and the evidence is limited.
How serious is the interaction between Methylprednisolone and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for increased corticosteroid effects if high doses or prolonged courses are used.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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