Drug interactions
Metoclopramide + Miconazole
Severity: Moderate
Metoclopramide and Miconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide is partly metabolised by CYP2D6, and strong inhibition of this enzyme raises metoclopramide exposure, increasing the risk of extrapyramidal symptoms, sedation and other adverse effects. Miconazole is mainly a CYP3A4 and CYP2C9 inhibitor with some 2D6 inhibition, so the effect is probably modest, particularly with topical use.
What this interaction means in plain words
Metoclopramide and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Miconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP2D6-mediated metabolism of metoclopramide, increasing its plasma concentration.
What to do
If systemic miconazole is used, consider reducing the metoclopramide dose and monitor for extrapyramidal symptoms and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metoclopramide and Miconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metoclopramide
Other interactions of Miconazole
Frequently asked questions
Can I take Metoclopramide with Miconazole?
MediHelp rates the interaction as moderate. Metoclopramide and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide is partly metabolised by CYP2D6, and strong inhibition of this enzyme raises metoclopramide exposure, increasing the risk of extrapyramidal symptoms, sedation and other adverse effects. Miconazole is mainly a CYP3A4 and CYP2C9 inhibitor with some 2D6 inhibition, so the effect is probably modest, particularly with topical use.
How serious is the interaction between Metoclopramide and Miconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If systemic miconazole is used, consider reducing the metoclopramide dose and monitor for extrapyramidal symptoms and sedation.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
