Drug interactions
Metoclopramide + Oxazepam
Severity: Moderate
Metoclopramide and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have sedating effects, so concurrent use can increase drowsiness and psychomotor impairment. Metoclopramide may also speed absorption of oral benzodiazepines.
What this interaction means in plain words
Metoclopramide and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression, with faster gastric emptying possibly hastening absorption.
What to do
Counsel about sedation and avoid driving. Reduce doses in elderly or frail patients if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Metoclopramide with Oxazepam?
MediHelp rates the interaction as moderate. Metoclopramide and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have sedating effects, so concurrent use can increase drowsiness and psychomotor impairment. Metoclopramide may also speed absorption of oral benzodiazepines.
How serious is the interaction between Metoclopramide and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about sedation and avoid driving. Reduce doses in elderly or frail patients if excessive drowsiness occurs.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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