Drug interactions
Metoclopramide + Oxybutynin
Severity: Moderate
Metoclopramide and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybutynin's anticholinergic action opposes the prokinetic, cholinergic-dependent effect of metoclopramide on gastric emptying. This reduces metoclopramide's efficacy but is not generally dangerous.
What this interaction means in plain words
Metoclopramide and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Oxybutynin belongs to Genitourinary.
Why it happens
Pharmacodynamic antagonism: muscarinic blockade counteracts metoclopramide's enhancement of gastrointestinal motility.
What to do
Monitor for loss of prokinetic benefit and consider a less anticholinergic bladder agent if gastrointestinal symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Oxybutynin
Frequently asked questions
Can I take Metoclopramide with Oxybutynin?
MediHelp rates the interaction as moderate. Metoclopramide and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxybutynin's anticholinergic action opposes the prokinetic, cholinergic-dependent effect of metoclopramide on gastric emptying. This reduces metoclopramide's efficacy but is not generally dangerous.
How serious is the interaction between Metoclopramide and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of prokinetic benefit and consider a less anticholinergic bladder agent if gastrointestinal symptoms worsen.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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