Drug interactions
Metoclopramide + Rasagiline
Severity: Major
Metoclopramide and Rasagiline: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide may promote catecholamine release and has been associated with hypertensive reactions in patients on monoamine oxidase inhibitors. Rasagiline also is a dopaminergic agent for Parkinson's disease, and metoclopramide's dopamine blockade can worsen parkinsonian symptoms.
What this interaction means in plain words
Metoclopramide and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Metoclopramide belongs to Gastrointestinal Tract; Rasagiline belongs to Central Nervous System.
Why it happens
Metoclopramide-induced catecholamine release combined with MAO inhibition, plus central dopamine D2 antagonism opposing antiparkinsonian therapy.
What to do
Avoid metoclopramide in patients with Parkinson's disease on rasagiline; use domperidone where available or another antiemetic without central dopamine blockade. If used, monitor blood pressure and motor function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Metoclopramide
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Metoclopramide with Rasagiline?
MediHelp rates the interaction as major. Metoclopramide and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metoclopramide may promote catecholamine release and has been associated with hypertensive reactions in patients on monoamine oxidase inhibitors. Rasagiline also is a dopaminergic agent for Parkinson's disease, and metoclopramide's dopamine blockade can worsen parkinsonian symptoms.
How serious is the interaction between Metoclopramide and Rasagiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid metoclopramide in patients with Parkinson's disease on rasagiline; use domperidone where available or another antiemetic without central dopamine blockade. If used, monitor blood pressure and motor function.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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