Drug interactions
Metoclopramide + Ropinirole
Severity: Major
Metoclopramide and Ropinirole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide blocks central dopamine receptors and opposes the effect of ropinirole, which can worsen parkinsonian symptoms. Loss of motor control may be significant.
What this interaction means in plain words
Metoclopramide and Ropinirole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Metoclopramide belongs to Gastrointestinal Tract; Ropinirole belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism: metoclopramide D2 receptor blockade versus ropinirole D2/D3 agonism.
What to do
Avoid metoclopramide in patients with Parkinson disease treated with dopamine agonists. Use domperidone where available or ondansetron for nausea.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Metoclopramide
Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Metoclopramide with Ropinirole?
MediHelp rates the interaction as major. Metoclopramide and Ropinirole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metoclopramide blocks central dopamine receptors and opposes the effect of ropinirole, which can worsen parkinsonian symptoms. Loss of motor control may be significant.
How serious is the interaction between Metoclopramide and Ropinirole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid metoclopramide in patients with Parkinson disease treated with dopamine agonists. Use domperidone where available or ondansetron for nausea.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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