Drug interactions
Metoclopramide + Suvorexant
Severity: Minor
Metoclopramide and Suvorexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence and impair psychomotor performance, so combined use may increase daytime drowsiness. No significant pharmacokinetic interaction is established.
What this interaction means in plain words
Metoclopramide and Suvorexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metoclopramide belongs to Gastrointestinal Tract; Suvorexant belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; no established pharmacokinetic mechanism.
What to do
Counsel the patient about additive drowsiness and advise against driving until the response is known. Use the lowest effective suvorexant dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoclopramide
Other interactions of Suvorexant
Frequently asked questions
Can I take Metoclopramide with Suvorexant?
MediHelp rates the interaction as minor. Metoclopramide and Suvorexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause somnolence and impair psychomotor performance, so combined use may increase daytime drowsiness. No significant pharmacokinetic interaction is established.
How serious is the interaction between Metoclopramide and Suvorexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about additive drowsiness and advise against driving until the response is known. Use the lowest effective suvorexant dose.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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