Drug interactions
Metolazone + Nadolol
Severity: Minor
Metolazone and Nadolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone and nadolol together produce additive blood pressure lowering. Thiazide-induced hypokalemia and a modest rise in glucose may also be relevant in susceptible patients.
What this interaction means in plain words
Metolazone and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metolazone belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects; diuretic-related potassium and metabolic changes.
What to do
Monitor blood pressure, heart rate and serum potassium after starting or adjusting either drug. Adjust doses if hypotension or bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metolazone and Nadolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metolazone
Other interactions of Nadolol
Frequently asked questions
Can I take Metolazone with Nadolol?
MediHelp rates the interaction as minor. Metolazone and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metolazone and nadolol together produce additive blood pressure lowering. Thiazide-induced hypokalemia and a modest rise in glucose may also be relevant in susceptible patients.
How serious is the interaction between Metolazone and Nadolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium after starting or adjusting either drug. Adjust doses if hypotension or bradycardia occurs.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
