Drug interactions
Metolazone + Nebivolol
Severity: Minor
Metolazone and Nebivolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone and nebivolol are both antihypertensive and their effects add together. Hypokalemia from the diuretic may increase arrhythmia risk in vulnerable patients.
What this interaction means in plain words
Metolazone and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metolazone belongs to Cardiovascular; Nebivolol belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering; diuretic-induced potassium loss.
What to do
Monitor blood pressure, heart rate and serum potassium when therapy is started or changed. Replace potassium if levels fall.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metolazone and Nebivolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metolazone
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Metolazone with Nebivolol?
MediHelp rates the interaction as minor. Metolazone and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metolazone and nebivolol are both antihypertensive and their effects add together. Hypokalemia from the diuretic may increase arrhythmia risk in vulnerable patients.
How serious is the interaction between Metolazone and Nebivolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium when therapy is started or changed. Replace potassium if levels fall.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
