Drug interactions
Metolazone + Probenecid
Severity: Moderate
Metolazone and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone may raise serum uric acid and weaken probenecid's uricosuric action. Gout control can be affected.
What this interaction means in plain words
Metolazone and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metolazone belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Thiazide-like diuretics compete for tubular anion secretion and cause volume contraction that enhances urate reabsorption.
What to do
Monitor serum uric acid and flare frequency. Adjust the probenecid dose if urate control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Metolazone
Frequently asked questions
Can I take Metolazone with Probenecid?
MediHelp rates the interaction as moderate. Metolazone and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone may raise serum uric acid and weaken probenecid's uricosuric action. Gout control can be affected.
How serious is the interaction between Metolazone and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and flare frequency. Adjust the probenecid dose if urate control worsens.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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