Drug interactions
Metolazone + Sitagliptin
Severity: Moderate
Metolazone and Sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone may raise blood glucose and reduce the effect of sitagliptin. Glycemic control may worsen after the diuretic is started.
What this interaction means in plain words
Metolazone and Sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metolazone belongs to Cardiovascular; Sitagliptin belongs to Endocrine.
Why it happens
Thiazide-like diuretics impair insulin secretion and sensitivity, opposing antihyperglycemic therapy.
What to do
Monitor blood glucose and HbA1c when metolazone is started or changed. Adjust the antidiabetic regimen if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Metolazone with Sitagliptin?
MediHelp rates the interaction as moderate. Metolazone and Sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone may raise blood glucose and reduce the effect of sitagliptin. Glycemic control may worsen after the diuretic is started.
How serious is the interaction between Metolazone and Sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when metolazone is started or changed. Adjust the antidiabetic regimen if needed.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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